PB1852 PROLIFERATION CAPACITY OF STROMAL PRECURSORS FROM THE BONE MARROW OF UNTREATED APLASTIC ANEMIA PATIENTS
نویسندگان
چکیده
منابع مشابه
ALLOGENIC BONE MARROW TRANSPLANTATION IN APLASTIC ANEMIA
Eighteen patients, twelve men and six women, with aplastic anemia underwent allogenic bone marrow transplantation (BMT) from HLA-matched siblings during the period of 1990 to 1996. The conditioning regimen was cyclophosphamide with or without busulfan, depending on the cause of aplasia. Antilymphocyte globulin (ALG) and cyclosporine were used for rejection and acute GVHD prophylaxis, respe...
متن کاملStromal progenitor cells in bone marrow of patients with aplastic anemia.
The pathogenesis of aplastic an~mia (AA), which is defined by pancytopema and hypocellularity of the bone mar~ow (BM), is still an unsolved problem and IS most probably heterogeneous. Hemopoietic stromal defects have been suggested as one of the possible pathophysiologic mechanisms for AA. Up to now, in all investigations on stromal cells of patients with AA, the fibroblast colony assay (CFU-F)...
متن کاملallogenic bone marrow transplantation in aplastic anemia
eighteen patients, twelve men and six women, with aplastic anemia underwent allogenic bone marrow transplantation (bmt) from hla-matched siblings during the period of 1990 to 1996. the conditioning regimen was cyclophosphamide with or without busulfan, depending on the cause of aplasia. antilymphocyte globulin (alg) and cyclosporine were used for rejection and acute gvhd prophylaxis, respective...
متن کاملBone marrow culture in aplastic anemia.
Blood and bone marrow granulocyte colony forming units (CFUc) were assayed in 46 patients with aplastic anemia, and the serum was examined for its inhibitory action on normal CFUc growth. All patients showed a gross reduction in colonies and clusters in incidence and absolute number in the bone marrow and blood. Two proliferative abnormalities of CFUc in aplastic anaemia were identified: a sign...
متن کاملStem cell factor stimulates the in vitro growth of bone marrow cells from aplastic anemia patients.
Aplastic anemia (AA) is a rare human bone marrow disorder of unknown etiology manifested by a strongly impaired growth of hematopoietic precursors. In this study, we examined the ability of recombinant human stem cell factor (SCF) to stimulate proliferation in vitro of bone marrow cells from 15 AA patients. All patients had been previously treated with antilymphocyte globulin (ALG). SCF, in com...
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ژورنال
عنوان ژورنال: HemaSphere
سال: 2019
ISSN: 2572-9241
DOI: 10.1097/01.hs9.0000565912.80839.3a